Assay Detail
Binding
CHEMBL907722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citaloporam from SERT in rat brain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.33 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218082 | — | — | 1 | 8.39 |
| CHEMBL385942 | — | — | 1 | 8.05 |
| CHEMBL214230 | — | — | 1 | 7.29 |
| CHEMBL273878 | — | — | 1 | 6.96 |
| CHEMBL217627 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218082 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL385942 | — | Ki | = | 8.82 | nM | 8.05 |
| CHEMBL214230 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL273878 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL217627 | — | Ki | = | 1070.0 | nM | 5.97 |