Assay Detail
Binding
CHEMBL907887
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Inhibition of rat DHODH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2383) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.58 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141732 | — | — | 1 | 7.68 |
| CHEMBL141047 | — | — | 1 | 7.64 |
| CHEMBL141086 | — | — | 1 | 6.60 |
| CHEMBL337130 | — | — | 1 | 6.55 |
| CHEMBL220927 | — | — | 1 | 6.53 |
| CHEMBL143438 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141732 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL141047 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL141086 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL337130 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL220927 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL143438 | — | IC50 | = | 31600.0 | nM | 4.50 |