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Assay Detail

CHEMBL907933

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ADMET
Cytotoxicity against ZR-75-1 cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type ZR-75-1
Confidence 1 — Organism
Curated By Autocuration

Target

ZR-75-1 (CHEMBL614393)
Type CELL-LINE
Organism Homo sapiens

Publication

Highly potent triazole-based tubulin polymerization inhibitors.
Zhang Q, Peng Y, Wang XI, Keenan SM, Arora S, Welsh WJ.
J Med Chem (2007) 50 : 749 -754
PubMed 17249649 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.01 9.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67 COMBRETASTATIN A4 -1.0 1 9.62
CHEMBL375206 1 7.62
CHEMBL376708 1 6.85
CHEMBL221628 1 6.51
CHEMBL428647 PACLITAXEL 4.0 1 6.51
CHEMBL220694 1 6.43
CHEMBL374568 1 6.28
CHEMBL107 COLCHICINE 4.0 1 6.28
CHEMBL386960 1 -
CHEMBL414531 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67 COMBRETASTATIN A4 IC50 = 0.24 nM 9.62
CHEMBL375206 IC50 = 23.8 nM 7.62
CHEMBL376708 IC50 = 141.0 nM 6.85
CHEMBL221628 IC50 = 308.0 nM 6.51
CHEMBL428647 PACLITAXEL IC50 = 308.0 nM 6.51
CHEMBL220694 IC50 = 367.0 nM 6.43
CHEMBL374568 IC50 = 522.0 nM 6.28
CHEMBL107 COLCHICINE IC50 = 522.0 nM 6.28
CHEMBL386960 IC50 - -
CHEMBL414531 IC50 - -