Assay Detail
Binding
CHEMBL908403
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Displacement of [3H]ZM-241385 from adenosine A2A receptor in rat striatal membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.77 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216269 | — | — | 1 | 5.96 |
| CHEMBL450341 | — | — | 1 | 5.57 |
| CHEMBL218132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216269 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL450341 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL218132 | — | Ki | - | — | - |