Assay Detail
Binding
CHEMBL908418
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Inhibition of JAK2
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.30 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221029 | — | — | 1 | 8.40 |
| CHEMBL218579 | — | — | 1 | 8.15 |
| CHEMBL221976 | — | — | 1 | 8.10 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.96 |
| CHEMBL220483 | — | — | 1 | 7.92 |
| CHEMBL222027 | — | — | 1 | 7.80 |
| CHEMBL218439 | — | — | 1 | 7.77 |
| CHEMBL374321 | — | — | 1 | 7.75 |
| CHEMBL375296 | — | — | 1 | 7.72 |
| CHEMBL384820 | — | — | 1 | 7.70 |
| CHEMBL221378 | — | — | 1 | 7.55 |
| CHEMBL375205 | — | — | 1 | 7.54 |
| CHEMBL375076 | — | — | 1 | 7.31 |
| CHEMBL218746 | — | — | 1 | 7.29 |
| CHEMBL220585 | — | — | 1 | 7.29 |
| CHEMBL220969 | — | — | 1 | 7.25 |
| CHEMBL221037 | — | — | 1 | 7.23 |
| CHEMBL385114 | — | — | 1 | 7.17 |
| CHEMBL221376 | — | — | 1 | 7.11 |
| CHEMBL376885 | — | — | 1 | 6.95 |
| CHEMBL221912 | — | — | 1 | 6.91 |
| CHEMBL557844 | — | — | 1 | 6.85 |
| CHEMBL218602 | — | — | 1 | 6.82 |
| CHEMBL373523 | — | — | 1 | 6.78 |
| CHEMBL220484 | — | — | 1 | 6.35 |
| CHEMBL323994 | — | — | 1 | 6.22 |
| CHEMBL221038 | — | — | 1 | 5.14 |
| CHEMBL222028 | — | — | 1 | - |
| CHEMBL374854 | — | — | 1 | - |
| CHEMBL217937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221029 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL218579 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL221976 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL220483 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL222027 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL218439 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL374321 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL375296 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL384820 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL221378 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL375205 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL375076 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL218746 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL220585 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL220969 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL221037 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL385114 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL221376 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL376885 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL221912 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL557844 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL218602 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL373523 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL220484 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL323994 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL221038 | — | IC50 | = | 7218.0 | nM | 5.14 |
| CHEMBL222028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374854 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217937 | — | IC50 | > | 10000.0 | nM | - |