Compound Detail
CHEMBL221376
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Basic Information
| ChEMBL ID | CHEMBL221376 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MRSNJDJDIJAPCO-HNNXBMFYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
396.5
MW (Da)
3.78
ALogP
8
HBA
1
HBD
86.3
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 7.11 | 7.11 | 77.0 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 6.61 | 6.61 | 245.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | IC50 | = | 77.0 | nM | 7.11 | Inhibition of JAK2 | 16934457 |
| Tyrosine-protein kinase JAK3 | IC50 | = | 245.0 | nM | 6.61 | Inhibition of JAK3 | 16934457 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16934457 | 10.1016/j.bmcl.2006.08.022 | Tyrosine-protein kinase JAK3 | 1 |
| 16934457 | 10.1016/j.bmcl.2006.08.022 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine