Assay Detail
Binding
CHEMBL908417
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Inhibition of JAK3
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.95 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.89 |
| CHEMBL218579 | — | — | 1 | 7.72 |
| CHEMBL221029 | — | — | 1 | 7.68 |
| CHEMBL218439 | — | — | 1 | 7.57 |
| CHEMBL375205 | — | — | 1 | 7.51 |
| CHEMBL323994 | — | — | 1 | 7.42 |
| CHEMBL374321 | — | — | 1 | 7.38 |
| CHEMBL221912 | — | — | 1 | 7.35 |
| CHEMBL220483 | — | — | 1 | 7.31 |
| CHEMBL557844 | — | — | 1 | 7.29 |
| CHEMBL222027 | — | — | 1 | 7.22 |
| CHEMBL384820 | — | — | 1 | 7.21 |
| CHEMBL375296 | — | — | 1 | 7.21 |
| CHEMBL221378 | — | — | 1 | 7.08 |
| CHEMBL221976 | — | — | 1 | 7.04 |
| CHEMBL385114 | — | — | 1 | 6.92 |
| CHEMBL376885 | — | — | 1 | 6.88 |
| CHEMBL375076 | — | — | 1 | 6.84 |
| CHEMBL220969 | — | — | 1 | 6.78 |
| CHEMBL220484 | — | — | 1 | 6.78 |
| CHEMBL221037 | — | — | 1 | 6.75 |
| CHEMBL221376 | — | — | 1 | 6.61 |
| CHEMBL373523 | — | — | 1 | 6.33 |
| CHEMBL220585 | — | — | 1 | 6.16 |
| CHEMBL218602 | — | — | 1 | 6.07 |
| CHEMBL218746 | — | — | 1 | 5.71 |
| CHEMBL221038 | — | — | 1 | 5.04 |
| CHEMBL374854 | — | — | 1 | - |
| CHEMBL222028 | — | — | 1 | - |
| CHEMBL217937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL218579 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL221029 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL218439 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL375205 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL323994 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL374321 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL221912 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL220483 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL557844 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL222027 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL384820 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL375296 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL221378 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL221976 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL385114 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL376885 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL375076 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL220969 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL220484 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL221037 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL221376 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL373523 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL220585 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL218602 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL218746 | — | IC50 | = | 1928.0 | nM | 5.71 |
| CHEMBL221038 | — | IC50 | = | 9097.0 | nM | 5.04 |
| CHEMBL374854 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217937 | — | IC50 | > | 10000.0 | nM | - |