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Assay Detail

CHEMBL908498

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Binding
Inhibition of bovine brain mitochondria MAOA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Subcellular Mitochondria
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Amine oxidase [flavin-containing] A (CHEMBL3254)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives.
Chimenti F, Maccioni E, Secci D, Bolasco A, Chimenti P, Granese A, Befani O, Turini P, Alcaro S, Ortuso F, Cardia MC, Distinto S.
J Med Chem (2007) 50 : 707 -712
PubMed 17253676 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 7.32 8.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220548 1 8.14
CHEMBL221392 1 7.92
CHEMBL385124 1 7.88
CHEMBL375007 1 7.72
CHEMBL220495 1 7.69
CHEMBL385117 1 7.67
CHEMBL425640 1 7.52
CHEMBL217916 1 7.45
CHEMBL375807 1 7.42
CHEMBL375539 1 7.39
CHEMBL385122 1 7.30
CHEMBL218073 1 7.18
CHEMBL221483 1 7.03
CHEMBL435310 1 7.00
CHEMBL374237 1 7.00
CHEMBL386941 1 6.85
CHEMBL375651 1 6.69
CHEMBL412711 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220548 Ki = 7.244 nM 8.14
CHEMBL221392 Ki = 12.02 nM 7.92
CHEMBL385124 Ki = 13.18 nM 7.88
CHEMBL375007 Ki = 19.05 nM 7.72
CHEMBL220495 Ki = 20.42 nM 7.69
CHEMBL385117 Ki = 21.38 nM 7.67
CHEMBL425640 Ki = 30.2 nM 7.52
CHEMBL217916 Ki = 35.48 nM 7.45
CHEMBL375807 Ki = 38.02 nM 7.42
CHEMBL375539 Ki = 40.74 nM 7.39
CHEMBL385122 Ki = 50.12 nM 7.30
CHEMBL218073 Ki = 66.07 nM 7.18
CHEMBL221483 Ki = 93.33 nM 7.03
CHEMBL435310 Ki = 100.0 nM 7.00
CHEMBL374237 Ki = 100.0 nM 7.00
CHEMBL386941 Ki = 141.25 nM 6.85
CHEMBL375651 Ki = 204.17 nM 6.69
CHEMBL412711 Ki = 1202.26 nM 5.92