Assay Detail
Functional
CHEMBL909352
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Inhibition of IL1-stimulated IL6 production in HFF cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.55 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 9.29 |
| CHEMBL219207 | — | — | 1 | 8.52 |
| CHEMBL384081 | — | — | 1 | 8.25 |
| CHEMBL375838 | — | — | 1 | 8.22 |
| CHEMBL219973 | — | — | 1 | 8.22 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.18 |
| CHEMBL373497 | — | — | 1 | 7.96 |
| CHEMBL219561 | — | — | 1 | 7.77 |
| CHEMBL386465 | — | — | 1 | 7.57 |
| CHEMBL216173 | — | — | 1 | 7.47 |
| CHEMBL386916 | — | — | 1 | 7.46 |
| CHEMBL219084 | — | — | 1 | 7.41 |
| CHEMBL374327 | — | — | 1 | 7.33 |
| CHEMBL219015 | — | — | 1 | 7.28 |
| CHEMBL219140 | — | — | 1 | 7.25 |
| CHEMBL216272 | — | — | 1 | 7.23 |
| CHEMBL425970 | — | — | 1 | 7.21 |
| CHEMBL219016 | — | — | 1 | 7.16 |
| CHEMBL216273 | — | — | 1 | 7.12 |
| CHEMBL219069 | — | — | 1 | 7.11 |
| CHEMBL219314 | — | — | 1 | 6.96 |
| CHEMBL375348 | — | — | 1 | 6.57 |
| CHEMBL386915 | — | — | 1 | 6.22 |
| CHEMBL373498 | — | — | 1 | - |
| CHEMBL219068 | — | — | 1 | - |
| CHEMBL218976 | — | — | 1 | - |
| CHEMBL220023 | — | — | 1 | - |
| CHEMBL218830 | — | — | 1 | - |
| CHEMBL435753 | — | — | 1 | - |
| CHEMBL373567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL219207 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL384081 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL375838 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL219973 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL131 | PREDNISOLONE | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL373497 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL219561 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL386465 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL216173 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL386916 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL219084 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL374327 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL219015 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL219140 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL216272 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL425970 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL219016 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL216273 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL219069 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL219314 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL375348 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL386915 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL373498 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL219068 | — | IC50 | - | — | - | |
| CHEMBL218976 | — | IC50 | - | — | - | |
| CHEMBL220023 | — | IC50 | - | — | - | |
| CHEMBL218830 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL435753 | — | IC50 | - | — | - | |
| CHEMBL373567 | — | IC50 | - | — | - | |
| CHEMBL218778 | — | IC50 | - | — | - | |
| CHEMBL219290 | — | IC50 | - | — | - | |
| CHEMBL219205 | — | IC50 | - | — | - | |
| CHEMBL263091 | — | IC50 | > | 2000.0 | nM | - |