Compound Detail

CHEMBL216173

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Cc1ccc(F)cc1C(C)(C)CC(O)(Cn1ccc(=O)c2ccccc21)C(F)(F)F

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL216173
Phase	Preclinical
Structure Type	MOL
InChI Key	JKPOACVGQYPLBU-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

421.4

MW (Da)

5.11

ALogP

HBA

HBD

42.2

PSA (Å²)

0.58

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 4 meas. best 8.0

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucocorticoid receptor CHEMBL2034	IC50	8.0	8.0	10.0	1
HFF CHEMBL614071	IC50	7.47	7.47	34.0	1
Mineralocorticoid receptor CHEMBL1994	IC50	6.92	6.92	120.0	1
Progesterone receptor CHEMBL208	IC50	6.62	6.62	240.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucocorticoid receptor	IC50	=	10.0	nM	8.0	Inhibition of tetramethylrhodamine labeled dexamethasone binding to GR by FP ass...	17181172
HFF	IC50	=	34.0	nM	7.47	Inhibition of IL1-stimulated IL6 production in HFF cells	17181172
Mineralocorticoid receptor	IC50	=	120.0	nM	6.92	Inhibition of tetramethylrhodamine labeled dexamethasone binding to MR by FP ass...	17181172
Progesterone receptor	IC50	=	240.0	nM	6.62	Inhibition of tetramethylrhodamine labeled RU486 binding to PR by FP assay	17181172

PubMed	DOI	Target Context	# Activities
17181172	10.1021/jm061273t	HFF	4
17181172	10.1021/jm061273t	HeLa	2
17181172	10.1021/jm061273t	Glucocorticoid receptor	1
17181172	10.1021/jm061273t	Mineralocorticoid receptor	1
17181172	10.1021/jm061273t	Progesterone receptor	1
17181172	10.1021/jm061273t	Mus musculus	1

Data from ChEMBL 36 via Core Engine