Assay Detail
Binding
CHEMBL909349
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Inhibition of tetramethylrhodamine labeled dexamethasone binding to GR by FP assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216272 | — | — | 1 | 8.52 |
| CHEMBL219207 | — | — | 1 | 8.52 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.52 |
| CHEMBL373497 | — | — | 1 | 8.40 |
| CHEMBL219314 | — | — | 1 | 8.40 |
| CHEMBL219973 | — | — | 1 | 8.30 |
| CHEMBL375838 | — | — | 1 | 8.22 |
| CHEMBL263091 | — | — | 1 | 8.10 |
| CHEMBL384081 | — | — | 1 | 8.10 |
| CHEMBL216273 | — | — | 1 | 8.00 |
| CHEMBL216173 | — | — | 1 | 8.00 |
| CHEMBL386465 | — | — | 1 | 8.00 |
| CHEMBL219561 | — | — | 1 | 7.96 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.82 |
| CHEMBL386915 | — | — | 1 | 7.82 |
| CHEMBL425970 | — | — | 1 | 7.66 |
| CHEMBL219069 | — | — | 1 | 7.55 |
| CHEMBL386916 | — | — | 1 | 7.47 |
| CHEMBL219084 | — | — | 1 | 7.47 |
| CHEMBL375348 | — | — | 1 | 7.42 |
| CHEMBL374327 | — | — | 1 | 7.32 |
| CHEMBL373498 | — | — | 1 | 7.27 |
| CHEMBL219140 | — | — | 1 | 7.11 |
| CHEMBL218830 | — | — | 1 | 6.96 |
| CHEMBL219015 | — | — | 1 | 6.92 |
| CHEMBL219016 | — | — | 1 | 6.90 |
| CHEMBL220023 | — | — | 1 | 6.19 |
| CHEMBL219068 | — | — | 1 | 6.16 |
| CHEMBL373567 | — | — | 1 | 6.11 |
| CHEMBL218976 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216272 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL219207 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL373497 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL219314 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL219973 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL375838 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL263091 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL384081 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL216273 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL216173 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL386465 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL219561 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL131 | PREDNISOLONE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL386915 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL425970 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL219069 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL386916 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL219084 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL375348 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL374327 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL373498 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL219140 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL218830 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL219015 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL219016 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL220023 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL219068 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL373567 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL218976 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL218778 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL219205 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL435753 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL219290 | — | IC50 | > | 2000.0 | nM | - |