Assay Detail

CHEMBL909383

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Agonist activity at rat D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

D(2) dopamine receptor (CHEMBL339) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

D(2) dopamine receptor (CHEMBL339) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL339

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	HEK293
Confidence	9 — Direct single protein target
Curated By	Expert

Target

D(2) dopamine receptor (CHEMBL339) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M, Miller LN, Uchic ME, Terranova MA, El-Kouhen OF, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Chang R, Martino BR, Wetter JM, Marsh KC, Martin R, Darbyshire JF, Gintant G, Hsieh GC, Moreland RB, Sullivan JP, Brioni JD, Stewart AO.
J Med Chem (2006) 49 : 7450 -7465
PubMed 17149874 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	9.18	9.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL53	APOMORPHINE	4.0	1	9.40
CHEMBL59	DOPAMINE	4.0	1	8.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL53	APOMORPHINE	EC50	=	0.4	nM	9.40
CHEMBL59	DOPAMINE	EC50	=	1.1	nM	8.96