Assay Detail
Binding
CHEMBL910339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human MC3R
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379054 | — | — | 1 | 9.00 |
| CHEMBL212614 | — | — | 1 | 9.00 |
| CHEMBL385000 | — | — | 1 | 8.96 |
| CHEMBL215833 | — | — | 1 | 8.48 |
| CHEMBL384176 | — | — | 1 | 8.15 |
| CHEMBL214410 | — | — | 1 | 7.77 |
| CHEMBL384774 | — | — | 1 | 7.46 |
| CHEMBL378837 | — | — | 1 | 7.12 |
| CHEMBL215576 | — | — | 1 | 6.69 |
| CHEMBL211975 | — | — | 1 | 6.62 |
| CHEMBL215895 | — | — | 1 | 6.45 |
| CHEMBL213284 | — | — | 1 | 6.34 |
| CHEMBL213566 | — | — | 1 | 6.33 |
| CHEMBL212332 | — | — | 1 | 5.94 |
| CHEMBL211699 | — | — | 1 | 5.92 |
| CHEMBL202699 | — | — | 1 | 5.76 |
| CHEMBL214770 | — | — | 1 | 5.38 |
| CHEMBL212855 | — | — | 1 | 5.21 |
| CHEMBL387246 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379054 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL212614 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL385000 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL215833 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL384176 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL214410 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL384774 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL378837 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL215576 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL211975 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL215895 | — | Ki | = | 352.0 | nM | 6.45 |
| CHEMBL213284 | — | Ki | = | 461.0 | nM | 6.34 |
| CHEMBL213566 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL212332 | — | Ki | = | 1143.0 | nM | 5.94 |
| CHEMBL211699 | — | Ki | = | 1195.0 | nM | 5.92 |
| CHEMBL202699 | — | Ki | = | 1727.0 | nM | 5.76 |
| CHEMBL214770 | — | Ki | = | 4122.0 | nM | 5.38 |
| CHEMBL212855 | — | Ki | = | 6107.0 | nM | 5.21 |
| CHEMBL387246 | — | Ki | = | 22562.0 | nM | 4.65 |