Compound Detail
CHEMBL214410
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CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O
Basic Information
| ChEMBL ID | CHEMBL214410 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BZEWEHPSOMSRJV-RWSKJCERSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
644.8
MW (Da)
1.25
ALogP
6
HBA
4
HBD
149.4
PSA (Ų)
0.13
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.8
Ki 3 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL259 | Ki | 8.89 | 8.89 | 1.3 | 1 |
| Melanocortin receptor 4 CHEMBL259 | EC50 | 8.8 | 8.8 | 1.6 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 8.43 | 8.43 | 3.7 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | Ki | 8.37 | 8.37 | 4.3 | 1 |
| Melanocortin receptor 3 CHEMBL4644 | EC50 | 8.25 | 8.25 | 5.6 | 1 |
| Melanocortin receptor 3 CHEMBL4644 | Ki | 7.77 | 7.77 | 17.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | Ki | = | 1.3 | nM | 8.89 | Binding affinity to human MC4R | 16766182 |
| Melanocortin receptor 4 | EC50 | = | 1.6 | nM | 8.8 | Agonist activity at human MC4R | 16766182 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 3.7 | nM | 8.43 | Agonist activity at human MC1R | 16766182 |
| Melanocyte-stimulating hormone receptor | Ki | = | 4.3 | nM | 8.37 | Binding affinity to human MC1R | 16766182 |
| Melanocortin receptor 3 | EC50 | = | 5.6 | nM | 8.25 | Agonist activity at human MC3R | 16766182 |
| Melanocortin receptor 3 | Ki | = | 17.0 | nM | 7.77 | Binding affinity to human MC3R | 16766182 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16766182 | 10.1016/j.bmcl.2006.05.087 | Melanocyte-stimulating hormone receptor | 3 |
| 16766182 | 10.1016/j.bmcl.2006.05.087 | Melanocortin receptor 3 | 3 |
| 16766182 | 10.1016/j.bmcl.2006.05.087 | Melanocortin receptor 4 | 3 |
Data from ChEMBL 36 via Core Engine