Assay Detail
Functional
CHEMBL910553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of anti CD3/anti CD28-induced T cell proliferation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424906 | — | — | 1 | 8.70 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.52 |
| CHEMBL189649 | — | — | 1 | 8.52 |
| CHEMBL216240 | — | — | 1 | 8.40 |
| CHEMBL217039 | — | — | 1 | 8.30 |
| CHEMBL214617 | — | — | 1 | 8.15 |
| CHEMBL273250 | — | — | 1 | 8.10 |
| CHEMBL386118 | — | — | 1 | 7.64 |
| CHEMBL385698 | — | — | 1 | 7.12 |
| CHEMBL186568 | — | — | 1 | 7.10 |
| CHEMBL364623 | — | — | 1 | 7.10 |
| CHEMBL365505 | — | — | 1 | 6.96 |
| CHEMBL188478 | — | — | 1 | 6.85 |
| CHEMBL189776 | — | — | 1 | 6.85 |
| CHEMBL384307 | — | — | 1 | 6.85 |
| CHEMBL386745 | — | — | 1 | 6.75 |
| CHEMBL360810 | — | — | 1 | 6.57 |
| CHEMBL405630 | — | — | 1 | 6.46 |
| CHEMBL407005 | — | — | 1 | 6.46 |
| CHEMBL385172 | — | — | 1 | 6.30 |
| CHEMBL386371 | — | — | 1 | 6.29 |
| CHEMBL384545 | — | — | 1 | 6.24 |
| CHEMBL189675 | — | — | 1 | 6.06 |
| CHEMBL131577 | — | — | 1 | 6.05 |
| CHEMBL307976 | — | — | 1 | - |
| CHEMBL386167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424906 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL189649 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL216240 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL217039 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL214617 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL273250 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL386118 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL385698 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL186568 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL364623 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL365505 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL188478 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL189776 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL384307 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL386745 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL360810 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL405630 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL407005 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL385172 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL386371 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL384545 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL189675 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL131577 | — | IC50 | = | 884.0 | nM | 6.05 |
| CHEMBL307976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL386167 | — | IC50 | > | 2000.0 | nM | - |