Assay Detail
ADMET
CHEMBL911912
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against Trypanosoma brucei by Alamar blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.63 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289 | HALOPROGIN | 4.0 | 1 | 6.52 |
| CHEMBL83747 | PSAMMAPLIN A | — | 1 | 5.58 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 5.55 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 5.48 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.39 |
| CHEMBL220636 | — | — | 1 | 5.28 |
| CHEMBL374772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289 | HALOPROGIN | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL83747 | PSAMMAPLIN A | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL411 | DIETHYLSTILBESTROL | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL456 | ETHACRYNIC ACID | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL51085 | EBSELEN | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL220636 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL374772 | — | EC50 | > | 100000.0 | nM | - |