Assay Detail
Functional
CHEMBL912246
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Dilatory activity against phenylephrine-induced contraction of Sprague-Dawley rat thoracic aorta
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.83 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218719 | — | — | 1 | 7.41 |
| CHEMBL441702 | GSK-270822A | — | 1 | 7.12 |
| CHEMBL218720 | GSK-466314A | — | 1 | 6.89 |
| CHEMBL375312 | — | — | 1 | 6.72 |
| CHEMBL218654 | — | — | 1 | 6.70 |
| CHEMBL384073 | GSK-180736A | — | 1 | 6.12 |
| CHEMBL427058 | GSK-466317A | — | 1 | - |
| CHEMBL217910 | — | — | 1 | - |
| CHEMBL374453 | GSK-299115A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218719 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL441702 | GSK-270822A | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL218720 | GSK-466314A | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL375312 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL218654 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL384073 | GSK-180736A | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL427058 | GSK-466317A | IC50 | - | — | - | |
| CHEMBL217910 | — | IC50 | - | — | - | |
| CHEMBL374453 | GSK-299115A | IC50 | - | — | - |