Assay Detail
Binding
CHEMBL912372
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Inhibition of Escherichia coli thymidylate synthase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Antibacterial agent discovery using thymidylate synthase biolibrary screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.87 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389051 | — | — | 1 | 7.22 |
| CHEMBL386442 | — | — | 1 | 6.52 |
| CHEMBL217765 | — | — | 1 | 6.40 |
| CHEMBL67116 | — | — | 1 | 6.22 |
| CHEMBL387007 | — | — | 1 | 6.05 |
| CHEMBL215133 | — | — | 1 | 6.05 |
| CHEMBL303171 | — | — | 1 | 5.96 |
| CHEMBL217227 | — | — | 1 | 5.96 |
| CHEMBL217760 | — | — | 1 | 5.92 |
| CHEMBL411871 | — | — | 1 | 5.85 |
| CHEMBL216560 | — | — | 1 | 5.82 |
| CHEMBL216675 | — | — | 1 | 5.39 |
| CHEMBL386685 | — | — | 1 | 5.36 |
| CHEMBL386282 | — | — | 1 | 5.28 |
| CHEMBL214872 | — | — | 1 | 5.07 |
| CHEMBL217000 | — | — | 1 | 4.89 |
| CHEMBL385891 | — | — | 1 | - |
| CHEMBL414689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389051 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL386442 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL217765 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL67116 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL387007 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL215133 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL303171 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL217227 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL217760 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL411871 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL216560 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL216675 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL386685 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL386282 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL214872 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL217000 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL385891 | — | Ki | > | 11000000.0 | nM | - |
| CHEMBL414689 | — | Ki | - | — | - |