Assay Detail
Functional
CHEMBL912473
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Negative inotropic activity assessed as decrease in developed tension in isolated guinea pig left atrium
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinolizidinyl derivatives as antiarrhythmic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.64 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375663 | — | — | 1 | 7.85 |
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL79 | LIDOCAINE | 4.0 | 1 | 7.77 |
| CHEMBL218302 | — | — | 1 | 7.51 |
| CHEMBL374923 | — | — | 1 | 7.42 |
| CHEMBL373373 | — | — | 1 | 7.23 |
| CHEMBL218892 | — | — | 1 | 6.85 |
| CHEMBL218303 | — | — | 1 | 6.80 |
| CHEMBL414124 | — | — | 1 | 6.80 |
| CHEMBL375968 | — | — | 1 | 6.60 |
| CHEMBL219516 | — | — | 1 | 6.54 |
| CHEMBL219401 | — | — | 1 | 6.51 |
| CHEMBL219546 | — | — | 1 | 6.34 |
| CHEMBL220081 | — | — | 1 | 6.22 |
| CHEMBL218853 | — | — | 1 | 6.21 |
| CHEMBL220082 | — | — | 1 | 6.20 |
| CHEMBL218250 | — | — | 1 | 6.12 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.47 |
| CHEMBL373706 | — | — | 1 | 5.46 |
| CHEMBL218251 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375663 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL640 | PROCAINAMIDE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL79 | LIDOCAINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL218302 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL374923 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL373373 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL218892 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL218303 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL414124 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL375968 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL219516 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL219401 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL219546 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL220081 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL218853 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL220082 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL218250 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1294 | QUINIDINE | EC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL373706 | — | EC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL218251 | — | EC50 | = | 8390.0 | nM | 5.08 |