Assay Detail
Functional
CHEMBL912474
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Negative chronotropic activity assessed as decrease in atrial rate in isolated guinea pig right atrium
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinolizidinyl derivatives as antiarrhythmic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.17 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218250 | — | — | 1 | 5.40 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.40 |
| CHEMBL633 | AMIODARONE | 4.0 | 1 | 5.25 |
| CHEMBL414124 | — | — | 1 | 5.18 |
| CHEMBL218251 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218250 | — | EC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL1294 | QUINIDINE | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL633 | AMIODARONE | EC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL414124 | — | EC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL218251 | — | EC50 | = | 23660.0 | nM | 4.63 |