Assay Detail
Binding
CHEMBL912581
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Inhibition of MAO-A in bovine brain mitochondria by fluorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Subcellular | Mitochondria |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Monoamine oxidase isoform-dependent tautomeric influence in the recognition of 3,5-diaryl pyrazole inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.46 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375966 | — | — | 1 | 9.00 |
| CHEMBL218323 | — | — | 1 | 8.69 |
| CHEMBL218324 | — | — | 1 | 8.52 |
| CHEMBL221593 | — | — | 1 | 7.85 |
| CHEMBL218059 | — | — | 1 | 6.52 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 6.42 |
| CHEMBL424940 | — | — | 1 | 5.82 |
| CHEMBL375616 | — | — | 1 | 5.64 |
| CHEMBL221293 | — | — | 1 | 5.52 |
| CHEMBL385397 | — | — | 1 | 5.39 |
| CHEMBL221629 | — | — | 1 | 5.20 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | 4.94 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375966 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL218323 | — | IC50 | = | 2.042 | nM | 8.69 |
| CHEMBL218324 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL221593 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL218059 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 380.19 | nM | 6.42 |
| CHEMBL424940 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL375616 | — | IC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL221293 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL385397 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL221629 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL972 | SELEGILINE | IC50 | = | 38018.94 | nM | 4.42 |