Assay Detail
Functional
CHEMBL913353
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Agonist activity at rat AR transfected in mouse C2C12 cells by luciferase reporter transactivation assay
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C2C12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.37 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220359 | — | — | 2 | 8.82 |
| CHEMBL425646 | — | — | 2 | 8.64 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 8.55 |
| CHEMBL374781 | — | — | 1 | 8.36 |
| CHEMBL218914 | — | — | 1 | 8.20 |
| CHEMBL2096842 | — | — | 1 | 6.58 |
| CHEMBL374121 | — | — | 1 | 6.57 |
| CHEMBL219198 | — | — | 1 | 6.50 |
| CHEMBL384533 | — | — | 1 | 6.42 |
| CHEMBL218809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220359 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL425646 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL27769 | STANOLONE | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL374781 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL218914 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL2096842 | — | EC50 | = | 265.0 | nM | 6.58 |
| CHEMBL374121 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL220359 | — | EC50 | = | 281.0 | nM | 6.55 |
| CHEMBL219198 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL384533 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL425646 | — | EC50 | = | 1298.0 | nM | 5.89 |
| CHEMBL218809 | — | EC50 | > | 1000.0 | nM | - |