Assay Detail
Functional
CHEMBL913355
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Antagonist activity against rat AR transfected in mouse C2C12 cells by luciferase reporter transactivation assay relative to DHT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C2C12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.90 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425646 | — | — | 1 | 7.22 |
| CHEMBL218809 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425646 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL218809 | — | IC50 | = | 260.0 | nM | 6.58 |