Assay Detail
Functional
CHEMBL913582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.17 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221655 | — | — | 1 | 7.66 |
| CHEMBL220692 | — | — | 1 | 7.52 |
| CHEMBL221654 | — | — | 1 | 7.21 |
| CHEMBL376909 | — | — | 1 | 6.89 |
| CHEMBL221955 | — | — | 1 | 6.88 |
| CHEMBL218097 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221655 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL220692 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL221654 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL376909 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL221955 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL218097 | — | IC50 | = | 149.0 | nM | 6.83 |