Assay Detail
Functional
CHEMBL913633
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Inhibition of thrombus formation in rabbit AV shunt thrombosis model
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.46 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378093 | — | — | 1 | 6.87 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 6.47 |
| CHEMBL222079 | — | — | 1 | 6.30 |
| CHEMBL374304 | — | — | 1 | 6.19 |
| CHEMBL374305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378093 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL206335 | RAZAXABAN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL222079 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL374304 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL374305 | — | IC50 | > | 780.0 | nM | - |