Assay Detail
Functional
CHEMBL914007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against on HIV1 3b infected C8166 cells assessed as syncytial cell formation after 3 days
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Bioactive lignans from Peperomia heyneana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.26 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.77 |
| CHEMBL225191 | PEPEROMIN A | — | 1 | 5.28 |
| CHEMBL559875 | PEPEROMIN B | — | 1 | 5.27 |
| CHEMBL225260 | — | — | 1 | 4.56 |
| CHEMBL224381 | PEPEROMIN C | — | 1 | 4.37 |
| CHEMBL223923 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL225191 | PEPEROMIN A | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL559875 | PEPEROMIN B | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL225260 | — | EC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL224381 | PEPEROMIN C | EC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL223923 | — | EC50 | = | 49800.0 | nM | 4.30 |