Assay Detail
ADMET
CHEMBL914959
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Cytotoxicity against human colchicine-resistant KBC2 cells in presence of 2.5 uM colchicine after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | KBC2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.78 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 6.19 |
| CHEMBL225565 | — | — | 1 | 5.52 |
| CHEMBL225604 | — | — | 1 | 5.48 |
| CHEMBL225562 | — | — | 1 | 5.46 |
| CHEMBL225369 | METHYL PAPYRIFERATE | — | 1 | 5.43 |
| CHEMBL388788 | — | — | 1 | 4.87 |
| CHEMBL387861 | METHYL SHOREATE | — | 1 | 4.70 |
| CHEMBL224197 | CABRALEAHYDROXYLACTONE | — | 1 | 4.69 |
| CHEMBL375698 | — | — | 1 | 4.54 |
| CHEMBL225315 | CABRALELACTONE | — | 1 | 4.54 |
| CHEMBL224814 | — | — | 1 | 4.53 |
| CHEMBL376338 | — | — | 1 | 4.44 |
| CHEMBL224816 | DIPTEROCARPOL | — | 1 | 4.42 |
| CHEMBL224087 | — | — | 1 | 4.36 |
| CHEMBL224050 | PAPYRIFERIC ACID | — | 1 | 4.22 |
| CHEMBL224481 | CABRALEONE | — | 1 | 4.21 |
| CHEMBL224139 | OCOTILLONE | — | 1 | 4.19 |
| CHEMBL224431 | — | — | 1 | 4.18 |
| CHEMBL374628 | HYDROXYHOPANONE | — | 1 | - |
| CHEMBL375731 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL225565 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL225604 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL225562 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL225369 | METHYL PAPYRIFERATE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL388788 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL387861 | METHYL SHOREATE | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL224197 | CABRALEAHYDROXYLACTONE | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL375698 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL225315 | CABRALELACTONE | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL224814 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL376338 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL224816 | DIPTEROCARPOL | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL224087 | — | IC50 | = | 43600.0 | nM | 4.36 |
| CHEMBL224050 | PAPYRIFERIC ACID | IC50 | = | 60100.0 | nM | 4.22 |
| CHEMBL224481 | CABRALEONE | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL224139 | OCOTILLONE | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL224431 | — | IC50 | = | 65500.0 | nM | 4.18 |
| CHEMBL374628 | HYDROXYHOPANONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL375731 | — | IC50 | > | 100000.0 | nM | - |