Assay Detail
Functional
CHEMBL915485
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Antagonist activity at rat UT receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Urotensin-II receptor ligands. From agonist to antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.75 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223905 | URANTIDE | — | 1 | 8.30 |
| CHEMBL387916 | — | — | 1 | 8.00 |
| CHEMBL389653 | — | — | 1 | 7.40 |
| CHEMBL389654 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223905 | URANTIDE | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL387916 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL389653 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL389654 | — | Kd | = | 50.12 | nM | 7.30 |