Compound Detail
CHEMBL223905
URANTIDE Enter ChEMBL ID:
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CC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL223905 |
| Name | URANTIDE |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | VXLUBANOZQJZFE-QVKHRKAHSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1075.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.3
Kd 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urotensin-2 receptor CHEMBL3764 | Ki | 8.3 | 8.3 | 5.0 | 3 |
| Urotensin-2 receptor CHEMBL4921 | Kd | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urotensin-2 receptor | Kd | = | 5.012 | nM | 8.3 | Antagonist activity at rat UT receptor | 16279788 |
| Urotensin-2 receptor | Ki | = | 5.012 | nM | 8.3 | Displacement of [125I]urotensin 2 from human UT receptor expressed in CHO-K1 cel... | 16279788 |
| Urotensin-2 receptor | Ki | = | 5.012 | nM | 8.3 | Displacement of [125I]urotensin-2 from human UT2 receptor expressed in CHO-K1 ce... | 19432421 |
| Urotensin-2 receptor | Ki | = | 5.012 | nM | 8.3 | Displacement of [125I]urotensin-2 from human recombinant UT receptor expressed i... | 24992374 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24992374 | 10.1021/jm500218x | Urotensin-2 receptor | 7 |
| 19432421 | 10.1021/jm900148c | Urotensin-2 receptor | 3 |
| 16279788 | 10.1021/jm058043j | Urotensin-2 receptor | 2 |
| 16279788 | 10.1021/jm058043j | Rattus norvegicus | 1 |
| 24992374 | 10.1021/jm500218x | Serum | 1 |
Data from ChEMBL 36 via Core Engine