Assay Detail
Functional
CHEMBL915849
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Inhibition of TNF alpha-induced necroptosis in FADD-deficient variant human Jurkat T cells assessed as cell viability after 24 hrs
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of tricyclic necroptosis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 51 | 5.80 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222286 | — | — | 1 | 6.82 |
| CHEMBL223735 | — | — | 1 | 6.80 |
| CHEMBL370438 | — | — | 1 | 6.68 |
| CHEMBL374761 | — | — | 1 | 6.55 |
| CHEMBL222046 | — | — | 1 | 6.55 |
| CHEMBL374521 | — | — | 1 | 6.54 |
| CHEMBL222786 | — | — | 1 | 6.41 |
| CHEMBL426573 | — | — | 1 | 6.36 |
| CHEMBL387398 | — | — | 1 | 6.34 |
| CHEMBL222330 | — | — | 1 | 6.17 |
| CHEMBL390560 | — | — | 1 | 6.16 |
| CHEMBL221781 | — | — | 1 | 6.12 |
| CHEMBL222155 | — | — | 1 | 6.08 |
| CHEMBL222091 | — | — | 1 | 6.04 |
| CHEMBL222329 | — | — | 1 | 6.02 |
| CHEMBL221838 | — | — | 1 | 5.96 |
| CHEMBL373939 | — | — | 1 | 5.92 |
| CHEMBL224031 | — | — | 1 | 5.75 |
| CHEMBL222094 | — | — | 1 | 5.68 |
| CHEMBL221839 | — | — | 1 | 5.58 |
| CHEMBL374798 | — | — | 1 | 5.57 |
| CHEMBL225574 | — | — | 1 | 5.51 |
| CHEMBL376242 | — | — | 1 | 5.46 |
| CHEMBL222799 | — | — | 1 | 5.43 |
| CHEMBL221837 | — | — | 1 | 5.37 |
| CHEMBL374152 | — | — | 1 | 5.32 |
| CHEMBL222801 | — | — | 1 | 5.30 |
| CHEMBL221349 | — | — | 1 | 5.29 |
| CHEMBL223374 | — | — | 1 | 5.29 |
| CHEMBL221346 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222286 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL223735 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL370438 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL374761 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL222046 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL374521 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL222786 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL426573 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL387398 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL222330 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL390560 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL221781 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL222155 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL222091 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL222329 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL221838 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL373939 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL224031 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL222094 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL221839 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL374798 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL225574 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL376242 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL222799 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL221837 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL374152 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL222801 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL221349 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL223374 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL221346 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL222737 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL222306 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL373687 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL374498 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL222393 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL221728 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL222986 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL385794 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL376046 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL222288 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL222135 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL373878 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL373609 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL223196 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL223264 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL376241 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL374813 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL225573 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL223375 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL223376 | — | EC50 | > | 50000.0 | nM | - |