Assay Detail
Binding
CHEMBL916757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATM kinase
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.51 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222102 | KU-55933 | — | 1 | 7.89 |
| CHEMBL373979 | — | — | 1 | 5.50 |
| CHEMBL374930 | — | — | 1 | 5.37 |
| CHEMBL223980 | — | — | 1 | 5.00 |
| CHEMBL222545 | — | — | 1 | 4.75 |
| CHEMBL221459 | — | — | 1 | 4.54 |
| CHEMBL374133 | — | — | 1 | - |
| CHEMBL222179 | — | — | 1 | - |
| CHEMBL374290 | — | — | 1 | - |
| CHEMBL373699 | — | — | 1 | - |
| CHEMBL223667 | — | — | 1 | - |
| CHEMBL375346 | — | — | 1 | - |
| CHEMBL223436 | — | — | 1 | - |
| CHEMBL225796 | — | — | 1 | - |
| CHEMBL221412 | — | — | 1 | - |
| CHEMBL222766 | — | — | 1 | - |
| CHEMBL222765 | — | — | 1 | - |
| CHEMBL223034 | — | — | 1 | - |
| CHEMBL223381 | — | — | 1 | - |
| CHEMBL223775 | — | — | 1 | - |
| CHEMBL222525 | — | — | 1 | - |
| CHEMBL222577 | — | — | 1 | - |
| CHEMBL223437 | — | — | 1 | - |
| CHEMBL222544 | — | — | 1 | - |
| CHEMBL225608 | — | — | 1 | - |
| CHEMBL225609 | — | — | 1 | - |
| CHEMBL389267 | — | — | 1 | - |
| CHEMBL223382 | — | — | 1 | - |
| CHEMBL223041 | — | — | 1 | - |
| CHEMBL222745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222102 | KU-55933 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL373979 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL374930 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL223980 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL222545 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL221459 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL223436 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222180 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL225796 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL221412 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL222766 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL222765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223034 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222179 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL221565 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223559 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223610 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225273 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224782 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL426894 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL222181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL373526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222577 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL222745 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223041 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223382 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225609 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL222544 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL375346 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL222525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223775 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL223381 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374133 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL374290 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL373699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL223667 | — | IC50 | > | 10000.0 | nM | - |