Assay Detail
Functional
CHEMBL917613
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Antiproliferative activity against MiaPaCa2 cells after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223643 | VALINOMYCIN | — | 1 | 9.00 |
| CHEMBL155600 | — | — | 1 | 5.16 |
| CHEMBL223641 | — | — | 1 | 4.82 |
| CHEMBL155379 | ICOSAHYDRODIBENZO[B,K][1,4,7,10,13,16]HEXAOXACYCLOOCTADECINE | — | 1 | 4.80 |
| CHEMBL223459 | — | — | 1 | 4.75 |
| CHEMBL220845 | — | — | 1 | 4.70 |
| CHEMBL222671 | — | — | 1 | 4.64 |
| CHEMBL345536 | — | — | 1 | 4.55 |
| CHEMBL154420 | — | — | 1 | 4.50 |
| CHEMBL374066 | — | — | 1 | 4.15 |
| CHEMBL155204 | — | — | 1 | - |
| CHEMBL425114 | — | — | 1 | - |
| CHEMBL373818 | — | — | 1 | - |
| CHEMBL376080 | — | — | 1 | - |
| CHEMBL375669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223643 | VALINOMYCIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL155600 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL223641 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL155379 | ICOSAHYDRODIBENZO[B,K][1,4,7,10,13,16]HEXAOXACYCLOOCTADECINE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL223459 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL220845 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL222671 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL345536 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL154420 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL374066 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL155204 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL425114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL373818 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376080 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL375669 | — | IC50 | > | 100000.0 | nM | - |