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Assay Detail

CHEMBL917650

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human serum BChE
16
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.
Ducho C, Görbig U, Jessel S, Gisch N, Balzarini J, Meier C.
J Med Chem (2007) 50 : 1335 -1346
PubMed 17328534 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.53 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL221156 1 6.46
CHEMBL375767 1 6.11
CHEMBL373537 3 6.10
CHEMBL1161929 1 5.64
CHEMBL375636 3 5.44
CHEMBL223807 1 5.34
CHEMBL376095 3 4.85
CHEMBL223232 1 -
CHEMBL376914 1 -
CHEMBL373463 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL221156 IC50 = 350.0 nM 6.46
CHEMBL375767 IC50 = 770.0 nM 6.11
CHEMBL373537 IC50 = 790.0 nM 6.10
CHEMBL373537 IC50 = 2300.0 nM 5.64
CHEMBL1161929 IC50 = 2300.0 nM 5.64
CHEMBL375636 IC50 = 3600.0 nM 5.44
CHEMBL223807 IC50 = 4600.0 nM 5.34
CHEMBL375636 IC50 = 4700.0 nM 5.33
CHEMBL376095 IC50 = 14000.0 nM 4.85
CHEMBL376095 IC50 = 40000.0 nM 4.40
CHEMBL223232 IC50 > 50000.0 nM -
CHEMBL376914 IC50 > 50000.0 nM -
CHEMBL375636 IC50 > 50000.0 nM -
CHEMBL373537 IC50 > 50000.0 nM -
CHEMBL373463 IC50 > 50000.0 nM -
CHEMBL376095 IC50 > 50000.0 nM -