Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL375636

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1cn([C@H]2C=C[C@@H](COP3(=O)OCc4cccc(-c5cccc6c5OC(C)(C)OC6)c4O3)O2)c(=O)[nH]c1=O

Basic Information

ChEMBL ID CHEMBL375636
Phase Preclinical
Structure Type MOL
InChI Key CCBOYGOTQIYLJA-CATCILLUSA-N
3
Targets
11
Activities
2
Assay Types
3
PK Parameters
5
Publications
0
Known Names

Molecular Properties

554.5
MW (Da)
4.34
ALogP
10
HBA
1
HBD
127.3
PSA (Ų)
0.36
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H27N2O9P
MW 554.49
Aromatic Rings 3
Heavy Atoms 39
NP-Likeness 0.57

Activity Summary

EC50 9 meas. best 6.46
IC50 2 meas. best 5.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
EC50 6.46 6.4 350.0 3
Human immunodeficiency virus 2
CHEMBL380
EC50 6.4 6.1583 400.0 6
Cholinesterase
CHEMBL1914
IC50 5.44 5.385 3600.0 2

Pharmacokinetic Data

Parameter Value Units Species
T1/2 14.0 hr -
T1/2 21.0 hr -
T1/2 16.0 hr -

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17328534 10.1021/jm0611713 Human immunodeficiency virus 2 6
17328534 10.1021/jm0611713 No relevant target 3
17328534 10.1021/jm0611713 Cholinesterase 3
17328534 10.1021/jm0611713 Human immunodeficiency virus 1 3
17328534 10.1021/jm0611713 ADMET 3

Data from ChEMBL 36 via Core Engine