Assay Detail
Binding
CHEMBL917979
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Binding affinity to human cloned muscarinic receptor M3 expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.88 | 9.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | 4.0 | 1 | 9.87 |
| CHEMBL219786 | — | — | 1 | 9.47 |
| CHEMBL376057 | — | — | 1 | 9.23 |
| CHEMBL375969 | — | — | 1 | 9.13 |
| CHEMBL385328 | — | — | 1 | 9.05 |
| CHEMBL222259 | — | — | 1 | 9.04 |
| CHEMBL219825 | — | — | 1 | 8.84 |
| CHEMBL376255 | — | — | 1 | 8.77 |
| CHEMBL45454 | — | — | 1 | 8.75 |
| CHEMBL376870 | — | — | 1 | 8.66 |
| CHEMBL375073 | — | — | 1 | 8.61 |
| CHEMBL220393 | — | — | 1 | 8.31 |
| CHEMBL375851 | — | — | 1 | 8.30 |
| CHEMBL373515 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376897 | METHSCOPOLAMINE | Ki | = | 0.1349 | nM | 9.87 |
| CHEMBL219786 | — | Ki | = | 0.3388 | nM | 9.47 |
| CHEMBL376057 | — | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL375969 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL385328 | — | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL222259 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL219825 | — | Ki | = | 1.445 | nM | 8.84 |
| CHEMBL376255 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL45454 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL376870 | — | Ki | = | 2.188 | nM | 8.66 |
| CHEMBL375073 | — | Ki | = | 2.455 | nM | 8.61 |
| CHEMBL220393 | — | Ki | = | 4.898 | nM | 8.31 |
| CHEMBL375851 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL373515 | — | Ki | = | 5.248 | nM | 8.28 |