Compound Detail
CHEMBL376870
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Basic Information
| ChEMBL ID | CHEMBL376870 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFCLHAWGKPEFIX-HSALFYBXSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
331.5
MW (Da)
4.65
ALogP
3
HBA
0
HBD
12.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 9.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 9.46 | 9.46 | 0.3 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 9.0 | 9.0 | 1.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 8.97 | 8.97 | 1.1 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 8.7 | 8.7 | 2.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 8.66 | 8.66 | 2.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Ki | = | 0.3467 | nM | 9.46 | Binding affinity to human cloned muscarinic receptor M1 expressed in CHO cells | 17305327 |
| Muscarinic acetylcholine receptor M4 | Ki | = | 1.0 | nM | 9.0 | Binding affinity to human cloned muscarinic receptor M4 expressed in CHO cells | 17305327 |
| Muscarinic acetylcholine receptor M2 | Ki | = | 1.072 | nM | 8.97 | Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cells | 17305327 |
| Muscarinic acetylcholine receptor M5 | Ki | = | 1.995 | nM | 8.7 | Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cells | 17305327 |
| Muscarinic acetylcholine receptor M3 | Ki | = | 2.188 | nM | 8.66 | Binding affinity to human cloned muscarinic receptor M3 expressed in CHO cells | 17305327 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17305327 | 10.1021/jm061374r | Muscarinic acetylcholine receptor M1 | 2 |
| 17305327 | 10.1021/jm061374r | Muscarinic acetylcholine receptor M2 | 2 |
| 17305327 | 10.1021/jm061374r | Muscarinic acetylcholine receptor M3 | 2 |
| 17305327 | 10.1021/jm061374r | Muscarinic acetylcholine receptor M4 | 2 |
| 17305327 | 10.1021/jm061374r | Muscarinic acetylcholine receptor M5 | 1 |
Data from ChEMBL 36 via Core Engine