Assay Detail
Binding
CHEMBL917981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human cloned muscarinic receptor M5 expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.95 | 9.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219786 | — | — | 1 | 9.97 |
| CHEMBL376057 | — | — | 1 | 9.70 |
| CHEMBL376897 | METHSCOPOLAMINE | 4.0 | 1 | 9.68 |
| CHEMBL375969 | — | — | 1 | 9.39 |
| CHEMBL222259 | — | — | 1 | 9.11 |
| CHEMBL219825 | — | — | 1 | 8.92 |
| CHEMBL385328 | — | — | 1 | 8.87 |
| CHEMBL376255 | — | — | 1 | 8.70 |
| CHEMBL376870 | — | — | 1 | 8.70 |
| CHEMBL45454 | — | — | 1 | 8.55 |
| CHEMBL220393 | — | — | 1 | 8.49 |
| CHEMBL375073 | — | — | 1 | 8.49 |
| CHEMBL375851 | — | — | 1 | 8.46 |
| CHEMBL373515 | — | — | 1 | 8.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219786 | — | Ki | = | 0.1072 | nM | 9.97 |
| CHEMBL376057 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL376897 | METHSCOPOLAMINE | Ki | = | 0.2089 | nM | 9.68 |
| CHEMBL375969 | — | Ki | = | 0.4074 | nM | 9.39 |
| CHEMBL222259 | — | Ki | = | 0.7762 | nM | 9.11 |
| CHEMBL219825 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL385328 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL376255 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL376870 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL45454 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL220393 | — | Ki | = | 3.236 | nM | 8.49 |
| CHEMBL375073 | — | Ki | = | 3.236 | nM | 8.49 |
| CHEMBL375851 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL373515 | — | Ki | = | 5.623 | nM | 8.25 |