Assay Detail
Binding
CHEMBL918951
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Displacement of [125I]SRIF-14 from SSTR of rat AR42J cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | AR-42J |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Somatostatin receptor-binding peptides suitable for tumor radiotherapy with Re-188 or Re-186. Chemistry and initial biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.00 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373632 | — | — | 1 | 10.00 |
| CHEMBL222751 | — | — | 1 | 9.40 |
| CHEMBL374316 | — | — | 1 | 9.15 |
| CHEMBL376001 | — | — | 1 | 8.82 |
| CHEMBL434761 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373632 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL222751 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL374316 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL376001 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL434761 | — | IC50 | = | 23.7 | nM | 7.62 |