Assay Detail
Binding
CHEMBL918952
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Displacement of [125I-Tyr-11]-SRIF from SSTR of human NCI-H69 cell membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Somatostatin receptor-binding peptides suitable for tumor radiotherapy with Re-188 or Re-186. Chemistry and initial biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.17 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437296 | — | — | 1 | 9.70 |
| CHEMBL376485 | — | — | 1 | 9.46 |
| CHEMBL376484 | — | — | 1 | 9.30 |
| CHEMBL426548 | — | — | 1 | 9.19 |
| CHEMBL3350037 | — | — | 1 | 8.96 |
| CHEMBL222699 | — | — | 1 | 8.80 |
| CHEMBL268060 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437296 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL376485 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL376484 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL426548 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL3350037 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL222699 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL268060 | — | IC50 | = | 1.6 | nM | 8.80 |