Assay Detail
Binding
CHEMBL919613
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Wistar Han rat hippocampal membranes
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.96 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.92 |
| CHEMBL389718 | — | — | 1 | 8.42 |
| CHEMBL224820 | — | — | 1 | 8.07 |
| CHEMBL222864 | — | — | 1 | 8.05 |
| CHEMBL221513 | — | — | 1 | 7.78 |
| CHEMBL426723 | — | — | 1 | 7.63 |
| CHEMBL225512 | — | — | 1 | 7.62 |
| CHEMBL390558 | — | — | 1 | 7.61 |
| CHEMBL222262 | — | — | 1 | 7.52 |
| CHEMBL221732 | — | — | 1 | 7.41 |
| CHEMBL225284 | — | — | 1 | 7.28 |
| CHEMBL225252 | — | — | 1 | 7.26 |
| CHEMBL449089 | — | — | 1 | 7.26 |
| CHEMBL225441 | — | — | 1 | 7.14 |
| CHEMBL376531 | — | — | 1 | 7.10 |
| CHEMBL222477 | — | — | 1 | 7.02 |
| CHEMBL224883 | — | — | 1 | 6.98 |
| CHEMBL222188 | — | — | 1 | 6.89 |
| CHEMBL390062 | — | — | 1 | 6.80 |
| CHEMBL225571 | — | — | 1 | 6.74 |
| CHEMBL222807 | — | — | 1 | 6.61 |
| CHEMBL222106 | — | — | 1 | 6.60 |
| CHEMBL28063 | — | — | 1 | 6.60 |
| CHEMBL221453 | — | — | 1 | 6.59 |
| CHEMBL376662 | — | — | 1 | 6.59 |
| CHEMBL222755 | — | — | 1 | 6.55 |
| CHEMBL224935 | — | — | 1 | 6.54 |
| CHEMBL374261 | — | — | 1 | 6.48 |
| CHEMBL224929 | — | — | 1 | 6.36 |
| CHEMBL222489 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL389718 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL224820 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL222864 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL221513 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL426723 | — | Ki | = | 23.2 | nM | 7.63 |
| CHEMBL225512 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL390558 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL222262 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL221732 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL225284 | — | Ki | = | 52.7 | nM | 7.28 |
| CHEMBL225252 | — | Ki | = | 54.4 | nM | 7.26 |
| CHEMBL449089 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL225441 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL376531 | — | Ki | = | 78.9 | nM | 7.10 |
| CHEMBL222477 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL224883 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL222188 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL390062 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL225571 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL222807 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL28063 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL222106 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL221453 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL376662 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL222755 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL224935 | — | Ki | = | 291.0 | nM | 6.54 |
| CHEMBL374261 | — | Ki | = | 332.0 | nM | 6.48 |
| CHEMBL224929 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL222489 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL374298 | — | Ki | = | 676.0 | nM | 6.17 |
| CHEMBL374297 | — | Ki | = | 911.0 | nM | 6.04 |
| CHEMBL388970 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL387738 | — | Ki | = | 3124.0 | nM | 5.50 |
| CHEMBL222603 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL222604 | — | Ki | - | — | - | |
| CHEMBL441560 | — | Ki | - | — | - | |
| CHEMBL222507 | — | Ki | - | — | - | |
| CHEMBL225171 | — | Ki | - | — | - | |
| CHEMBL222275 | — | Ki | - | — | - |