Assay Detail
Binding
CHEMBL921168
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Inhibition of FLAG-tagged HDAC1 expressed in human 293T cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.39 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360194 | — | — | 1 | 9.40 |
| CHEMBL259517 | — | — | 1 | 6.02 |
| CHEMBL113003 | — | — | 1 | 5.91 |
| CHEMBL427776 | — | — | 1 | 5.58 |
| CHEMBL140000 | — | — | 1 | 5.53 |
| CHEMBL259434 | — | — | 1 | 5.53 |
| CHEMBL259708 | — | — | 1 | 5.48 |
| CHEMBL261492 | — | — | 1 | 5.29 |
| CHEMBL409526 | — | — | 1 | 5.20 |
| CHEMBL261272 | — | — | 1 | 5.02 |
| CHEMBL261587 | — | — | 1 | 5.01 |
| CHEMBL264411 | — | — | 1 | 4.99 |
| CHEMBL263884 | — | — | 1 | 4.98 |
| CHEMBL409860 | — | — | 1 | 4.78 |
| CHEMBL264926 | — | — | 1 | 4.72 |
| CHEMBL406734 | — | — | 1 | 4.64 |
| CHEMBL260080 | — | — | 1 | 4.55 |
| CHEMBL259826 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360194 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL259517 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL113003 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL427776 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL140000 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL259434 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL259708 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL261492 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL409526 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL261272 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL261587 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL264411 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL263884 | — | IC50 | = | 10540.0 | nM | 4.98 |
| CHEMBL409860 | — | IC50 | = | 16750.0 | nM | 4.78 |
| CHEMBL264926 | — | IC50 | = | 19190.0 | nM | 4.72 |
| CHEMBL406734 | — | IC50 | = | 22860.0 | nM | 4.64 |
| CHEMBL260080 | — | IC50 | = | 28440.0 | nM | 4.55 |
| CHEMBL259826 | — | IC50 | = | 38280.0 | nM | 4.42 |