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Assay Detail

CHEMBL921173

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells after 48 hrs by One aqueous proliferation assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).
Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M.
Bioorg Med Chem (2008) 16 : 2011 -2033
PubMed 18054239 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.35 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL259517 1 6.10
CHEMBL260080 1 6.05
CHEMBL409526 1 5.82
CHEMBL427776 1 5.82
CHEMBL259708 1 5.82
CHEMBL259434 1 5.72
CHEMBL259826 1 5.42
CHEMBL263884 1 5.40
CHEMBL409860 1 5.40
CHEMBL261492 1 5.40
CHEMBL113003 1 5.30
CHEMBL264926 1 4.77
CHEMBL261587 1 4.75
CHEMBL261272 1 4.68
CHEMBL406734 1 4.66
CHEMBL264411 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL259517 IC50 = 800.0 nM 6.10
CHEMBL260080 IC50 = 900.0 nM 6.05
CHEMBL409526 IC50 = 1500.0 nM 5.82
CHEMBL427776 IC50 = 1500.0 nM 5.82
CHEMBL259708 IC50 = 1500.0 nM 5.82
CHEMBL259434 IC50 = 1900.0 nM 5.72
CHEMBL259826 IC50 = 3800.0 nM 5.42
CHEMBL263884 IC50 = 4000.0 nM 5.40
CHEMBL409860 IC50 = 4000.0 nM 5.40
CHEMBL261492 IC50 = 4000.0 nM 5.40
CHEMBL113003 IC50 = 5000.0 nM 5.30
CHEMBL264926 IC50 = 17000.0 nM 4.77
CHEMBL261587 IC50 = 18000.0 nM 4.75
CHEMBL261272 IC50 = 21000.0 nM 4.68
CHEMBL406734 IC50 = 22000.0 nM 4.66
CHEMBL264411 IC50 = 32000.0 nM 4.50