Assay Detail
Functional
CHEMBL921176
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Cytotoxicity against human Jurkat cells after 48 hrs by One aqueous proliferation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.69 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261492 | — | — | 1 | 6.40 |
| CHEMBL261272 | — | — | 1 | 5.57 |
| CHEMBL264926 | — | — | 1 | 5.55 |
| CHEMBL406734 | — | — | 1 | 5.52 |
| CHEMBL264411 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261492 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL261272 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL264926 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL406734 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL264411 | — | IC50 | = | 4000.0 | nM | 5.40 |