Assay Detail
ADMET
CHEMBL921270
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Inhibition of CYP3A4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.95 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261805 | — | — | 1 | 5.47 |
| CHEMBL408712 | — | — | 1 | 5.12 |
| CHEMBL258951 | — | — | 1 | 5.11 |
| CHEMBL258648 | — | — | 1 | 4.92 |
| CHEMBL411062 | — | — | 1 | 4.82 |
| CHEMBL413828 | — | — | 1 | 4.82 |
| CHEMBL261146 | — | — | 1 | 4.77 |
| CHEMBL260298 | — | — | 1 | 4.77 |
| CHEMBL430051 | — | — | 1 | 4.72 |
| CHEMBL411082 | — | — | 1 | - |
| CHEMBL261253 | — | — | 1 | - |
| CHEMBL411074 | — | — | 1 | - |
| CHEMBL410659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261805 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL408712 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL258951 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL258648 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL411062 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL413828 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL261146 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL260298 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL430051 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL411082 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL261253 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL411074 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL410659 | — | IC50 | > | 20000.0 | nM | - |