Assay Detail
Binding
CHEMBL921466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type IV secretion-like conjugative transfer relaxase protein TraI (CHEMBL4296318) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain SMS-3-5 / SECEC) |
Publication
Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265450 | IMIDODIPHOSPHATE | — | 1 | 8.70 |
| CHEMBL180570 | MEDRONIC ACID | 3.0 | 1 | 8.52 |
| CHEMBL12318 | CLODRONIC ACID | 3.0 | 1 | 8.52 |
| CHEMBL871 | ETIDRONIC ACID | 4.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265450 | IMIDODIPHOSPHATE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL180570 | MEDRONIC ACID | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL12318 | CLODRONIC ACID | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL871 | ETIDRONIC ACID | Ki | = | 3.0 | nM | 8.52 |