Compound Detail
CHEMBL265450
IMIDODIPHOSPHATE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL265450 |
| Name | IMIDODIPHOSPHATE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GNGSOPFGGKKDQP-UHFFFAOYSA-N |
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
177.0
MW (Da)
-1.24
ALogP
2
HBA
5
HBD
127.1
PSA (Ų)
0.33
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.37
Ki 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type IV secretion-like conjugative transfer relaxase protein TraI CHEMBL4296318 | Ki | 8.7 | 8.635 | 2.0 | 2 |
| Escherichia coli CHEMBL354 | EC50 | 6.37 | 5.685 | 430.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type IV secretion-like conjugative transfer relaxase protein TraI | Ki | = | 2.0 | nM | 8.7 | Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as o... | 17630285 |
| Type IV secretion-like conjugative transfer relaxase protein TraI | Ki | = | 2.7 | nM | 8.57 | Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as o... | 17630285 |
| Escherichia coli | EC50 | = | 430.0 | nM | 6.37 | Cytotoxicity against tetracycline-resistant F plasmid positive Escherichia coli ... | 17630285 |
| Escherichia coli | EC50 | = | 10000.0 | nM | 5.0 | Inhibition of conjugate DNA transfer between tetracycline-resistant F plasmid po... | 17630285 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17630285 | 10.1073/pnas.0702760104 | Escherichia coli | 7 |
| 17630285 | 10.1073/pnas.0702760104 | Type IV secretion-like conjugative transfer relaxase protein TraI | 5 |
| 8246232 | 10.1021/jm00075a019 | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine