Assay Detail
ADMET
CHEMBL921646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective small-molecule human Urotensin-II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.49 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254356 | — | — | 1 | 6.12 |
| CHEMBL256937 | — | — | 1 | 6.09 |
| CHEMBL255509 | — | — | 1 | 5.80 |
| CHEMBL255462 | — | — | 1 | 5.77 |
| CHEMBL257150 | — | — | 1 | 5.66 |
| CHEMBL402805 | — | — | 1 | 5.64 |
| CHEMBL257767 | — | — | 1 | 5.64 |
| CHEMBL256989 | — | — | 1 | 5.54 |
| CHEMBL402813 | — | — | 1 | 5.50 |
| CHEMBL404289 | — | — | 1 | 5.46 |
| CHEMBL258251 | — | — | 1 | 5.43 |
| CHEMBL402520 | — | — | 1 | 5.32 |
| CHEMBL257171 | — | — | 1 | 5.29 |
| CHEMBL256721 | — | — | 1 | 5.17 |
| CHEMBL255460 | — | — | 1 | 5.10 |
| CHEMBL257415 | — | — | 1 | 5.08 |
| CHEMBL256988 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254356 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL256937 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL255509 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL255462 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL257150 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL402805 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL257767 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL256989 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL402813 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL404289 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL258251 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL402520 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL257171 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL256721 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL255460 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL257415 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL256988 | — | IC50 | = | 21000.0 | nM | 4.68 |