Assay Detail
Binding
CHEMBL921732
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Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid
15
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 9 | - | - |
| IC50 | 6 | 6.69 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76084 | — | — | 2 | 7.24 |
| CHEMBL139 | DICLOFENAC | 4.0 | 2 | 7.17 |
| CHEMBL407109 | — | — | 2 | 7.11 |
| CHEMBL76154 | — | — | 2 | 6.63 |
| CHEMBL258738 | — | — | 2 | 6.16 |
| CHEMBL259842 | — | — | 2 | 5.80 |
| CHEMBL259218 | — | — | 1 | - |
| CHEMBL408156 | — | — | 1 | - |
| CHEMBL260111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76084 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL407109 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL76154 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL258738 | — | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL259842 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL259218 | — | Inhibition | = | 40.0 | % | - |
| CHEMBL259842 | — | Inhibition | = | 55.0 | % | - |
| CHEMBL76154 | — | Inhibition | = | 90.0 | % | - |
| CHEMBL258738 | — | Inhibition | = | 80.0 | % | - |
| CHEMBL408156 | — | Inhibition | = | 35.0 | % | - |
| CHEMBL76084 | — | Inhibition | = | 100.0 | % | - |
| CHEMBL260111 | — | Inhibition | = | 30.0 | % | - |
| CHEMBL139 | DICLOFENAC | Inhibition | = | 90.0 | % | - |
| CHEMBL407109 | — | Inhibition | = | 75.0 | % | - |