Assay Detail
Binding
CHEMBL922696
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Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C6 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.29 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358043 | HETEROCODEINE | — | 1 | 8.96 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.77 |
| CHEMBL410907 | — | — | 1 | 8.68 |
| CHEMBL261048 | — | — | 1 | 7.64 |
| CHEMBL258669 | — | — | 1 | 6.91 |
| CHEMBL408422 | — | — | 1 | 6.52 |
| CHEMBL409743 | — | — | 1 | 6.28 |
| CHEMBL485 | CODEINE | 4.0 | 1 | 6.14 |
| CHEMBL412301 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358043 | HETEROCODEINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL70 | MORPHINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL410907 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL261048 | — | Ki | = | 22.9 | nM | 7.64 |
| CHEMBL258669 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL408422 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL409743 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL485 | CODEINE | Ki | = | 727.0 | nM | 6.14 |
| CHEMBL412301 | — | Ki | = | 1910.0 | nM | 5.72 |