Assay Detail
Binding
CHEMBL923035
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Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.43 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.95 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 8.10 |
| CHEMBL1162116 | — | — | 1 | 7.04 |
| CHEMBL77793 | — | — | 1 | 6.92 |
| CHEMBL134641 | SABCOMELINE | 2.0 | 1 | 6.64 |
| CHEMBL151938 | MILAMELINE | 2.0 | 1 | 5.25 |
| CHEMBL258907 | — | — | 1 | 5.23 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.18 |
| CHEMBL259662 | — | — | 1 | 5.08 |
| CHEMBL259344 | — | — | 1 | 5.08 |
| CHEMBL320820 | — | — | 1 | 4.96 |
| CHEMBL105457 | — | — | 1 | 4.96 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.92 |
| CHEMBL258906 | — | — | 1 | 4.85 |
| CHEMBL12587 | MUSCARINE | — | 1 | 4.74 |
| CHEMBL258905 | — | — | 1 | 4.72 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 4.69 |
| CHEMBL64000 | — | — | 1 | 4.67 |
| CHEMBL402473 | — | — | 1 | 4.67 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 4.53 |
| CHEMBL259131 | — | — | 1 | 4.28 |
| CHEMBL541424 | — | — | 1 | 4.03 |
| CHEMBL294273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | Ki | = | 1.122 | nM | 8.95 |
| CHEMBL21536 | XANOMELINE | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1162116 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL77793 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL134641 | SABCOMELINE | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL151938 | MILAMELINE | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL258907 | — | Ki | = | 5888.44 | nM | 5.23 |
| CHEMBL550 | PILOCARPINE | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL259662 | — | Ki | = | 8317.64 | nM | 5.08 |
| CHEMBL259344 | — | Ki | = | 8317.64 | nM | 5.08 |
| CHEMBL320820 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL105457 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL14 | CARBACHOL | Ki | = | 12022.64 | nM | 4.92 |
| CHEMBL258906 | — | Ki | = | 14125.38 | nM | 4.85 |
| CHEMBL12587 | MUSCARINE | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL258905 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | Ki | = | 20417.38 | nM | 4.69 |
| CHEMBL64000 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL402473 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL7303 | ARECOLINE | Ki | = | 29512.09 | nM | 4.53 |
| CHEMBL259131 | — | Ki | = | 52480.75 | nM | 4.28 |
| CHEMBL541424 | — | Ki | = | 93325.43 | nM | 4.03 |
| CHEMBL294273 | — | Ki | = | 281838.29 | nM | - |